With a bigger display 2x scaling might be too big. I'm trying out experimental support for fractional scaling in Gnome. To opt out again it is necessary to undo this experimental features setting:
$ gsettings set org.gnome.mutter experimental-features "['scale-monitor-framebuffer']"
In addition to fractional scaling that setting allows different scaling factors per monitor!
The only issue I'm seeing so far is that apps running with XWayland look fuzzy. That includes web browsers. But! Firefox and Chrome both have opt-in support for Wayland which fixes the problem.